CHARACTERISATION

• Detection of impurities, degradation products,
• Determination of shelf-life, normal or accelerated conditions,
• Active ingredient(s) quantification.

DERMAL ABSORPTION STUDIES

Identification of absorption and/or metabolisation processes after topical application onto the skin:

• Using in vitro models such as Franz cells, on animals or human skin,
• Finite or infinite dose,
• Occlusive or non occlusive system

IN-VITRO METABOLISM

To determinate metabolic or enzymatic activity induced by a new active ingredient:

• Metabolism enzymatic identification,
• Induction/ inhibition studies,
• In vitro and in vivo metabolic profile,
• Microsomes and hepatocytes.

ANALYTICAL METHODS

To quantify accurately active ingredients or metabolites in all the substrates and compartments generated, the extraction procedures and analytical methods used are fully validated.

• Quantification of radiolabelled entities by liquid scintillation counting,
• Quantification of non radiolabelled entities by various chromatography technics, mainly LC/MS-MS.